Theme 3 : Evasion of the antiviral response by RSV


As numerous viruses, Respiratory Syncytial Virus has evolved mechanisms to hijack the innate immune response. The non-structural NS1 and NS2 proteins of RSV have been identified as multifunctional proteins important in RSV’s subversion of the innate immune response. The underlying mechanisms are far from being fully understood, but it is clear that the NS proteins impede multiple steps in the signaling cascade leading to type I and III IFNs secretion and IFN-mediated signaling. Our work in progress is to further describe the role of NS1 and NS2 in the modulation of the antiviral/proinflammatory response in airway epithelial cells.