2019
 

M. Mariani, P. Dasmeh, A. Fortin, E. Caron, M. Kalamujic, A. Harrison, D. I. Hotea, D.M. Kasumba, S. Cervantes-Ortiz, E. Mukawera, A. Serohijos and N. Grandvaux (2019)

IFNβ and TNFα cooperate to induce a STAT1-independent antiviral and immunoregulatory program via non-canonical STAT2 and IRF9 pathways

Posted as preprint on bioRxiv, doi: 10.1101/273623

Cells 2019, 8(8), 919.

Grandvaux N, McCormick C. (2019)

CSV2018: The 2nd Symposium of the Canadian Society for Virology.

Viruses. 2019 Jan 18;11(1). pii: E79. doi: 10.3390/v11010079.

Kasumba DM, Grandvaux N. (2019)

Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome.

Trends Pharmacol Sci. pii: S0165-6147(18)30228-1.

doi: 10.1016/j.tips.2018.12.003.

 
2018

 

C. Petes, M. Mariani, Y. Yang, N. Grandvaux, and K. Gee (2018)

IL-30-induced signaling is dependent on engagement of WSX-1 receptor subunit and STAT3 activation in human immune cells.

Frontiers Immunol. 15;9:256 

 

N. Zamorano Cuervo, Q. Osseman and N. Grandvaux (2018)

Analysis of whole cell extracts distinguishes distinct polymerization states of MAVS during virus infection.

Viruses. 10(2): 56 

 

S. Rengachari, S. Groiss, J. Devos, E. Caron, N. Grandvaux and D. Panne (2018)

The structure of IRF9 transactivation domain reveals molecular insights into ISGF3 assembly.

Preprint: BioRxiv http://dx.doi.org/10.1101/131714

PNAS. pii: 201718426

2017

A.C. Robitaille, E. Caron, N. Zucchini, E. Mukawera, D. Adam, M. Mariani, A. Gélinas, A. Fortin, e. Brochiero and N. Grandvaux* (2017)

DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection.

Preprint: BioRxiv doi.org/10.1101/163360

Sci. Rep.7(1):17388. 

D. Planas, Y. Zhang, P. Monteiro, J.P. Goulet, A. Gosselin, N. Grandvaux, A. Fassati, J.P. Routy, and P. Ancuta (2017)

HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.

JCI Insights. 2(15):e93230.

V. Williams, AA Grosset, N. Zamorano, Y. St Pierre, MP Sylvestre, L. Gaboury and N. Grandvaux (2017)

Detection of IKK by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.

BMC Cancer. 22;17(1):356. 

C. McCormick and N. Grandvaux (2017)

1st Workshop of the Canadian Society for Virology

Viruses. 20;9(3). pii: E54. 

2016

S. Cervantes-Ortiz, N. Zamorano Cuervo and N. Grandvaux (2016)

Respiratory Syncytial Virus and Stress responses : impact on replication and physiopathology.

Viruses 8, 124. 

A. Robitaille, M. Mariani, A. Fortin and N. Grandvaux (2016)

A high resolution method to monitor phosphorylation-dependent activation of IRF3

J. Vis Exp. 107, e53723, doi:10.3791/53723.

2015

E. Mukawera, S. Chartier, V. Williams, P. Pagano, R. Lapointe and N. Grandvaux (2015).

Redox-modulating agents target NOX2-dependent IKK oncogenic kinase expression and proliferation in human breast cancer cell lines.

Redox Biol. 6: 9-18

N. Grandvaux, M. Mariani and K. Fink (2015).

Lung epithelial NOX/DUOX and respiratory virus infections

Clinical Sci. 128(6):337-47. 

2014

L.A. Hanafia, D. Gauchat, J. Godin- Ethier, J.B. Duvignaud, D. Leclerc, N. Grandvaux and R. Lapointe (2014).

Fludarabine down- regulates indoleamine 2,3-dioxygenase in tumors via a proteasome-mediated degradation mechanism.

Plos One 9(6):e99211. 

N. Grandvaux, X. Guan, F. Yoboua, N. Zucchini, K. Fink, P. Doyon, L. Martin, M. Servant and S. Chartier (2014).

Sustained activation of IRF-3 during infection by paramyxoviruses requires MDA5.

J. Innate Immun. 6:650-662 

2013

K. Fink and N. Grandvaux (2013).

STAT2 and IRF9 : beyond ISGF3

 JAK-STAT 2(4):e27521

N. Marr, S. E. Turvey and N. Grandvaux (2013).

Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective.

Trends Microbiol. 21(11):568-74 

45.   M. Baril, S. Es-Saad, L. Chatel-Chaix, M.A. Germain, K. Fink, K. Audette, A.S. Guenier1, J. Duchaine, M. Servant, N. Grandvaux and D. Lamarre (2013).

Genome wide RNAi screen reveals novel roles of spliceosomal proteins and of WNT/CTNNB1 signaling pathway in regulation of innate antiviral responses.

Plos Pathogens 9(6), e1003416  Epub juin 2013 

K. Fink, L. Martin, E. Mukawera, S. Chartier, X. De Deken, E. Brochiero, F. Miot and  N. Grandvaux (2013).

IFNβ/TNFα synergism induces a non-canonical STAT2/IRF9-dependent pathway triggering a novel DUOX2 NADPH Oxidase-mediated airway antiviral response.

Cell Res.  23(5):673-690, 2013 

        

F. Chouinard, C. Turcotte, X. Guan, M.C. Larose, S. Poirier, L. Bouchard, V. Provost, L. Flamand, N. Grandvaux, N. Flamand. (2013)

2 2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

J. Leuk. Biol., 93(2) :267-276. 

2012

N. Zucchini, V. Williams and N. Grandvaux (2012)

IRF-3 thiol residues are not critical for its activation following virus infection

JICR. 32(9) 

L. Jouan, L. Chatel-Chaix, P. Melançon, I.G. Rodrigue-Gervais, V.A. Raymond, S. Selliah, M. Bilodeau, N. Grandvaux and D. Lamarre (2012).

Targeted impairment of innate antiviral responses in liver of chronic Hepatitis C patients.

J. Hepatology. 56(1):70-7.  

2011

E. Maillé, N.T. Trinh, A. Privé, C. Bilodeau, E. Bissonnette, N. Grandvaux and E. Brochiero  (2011).

Regulation by TNFα of normal and cystic fibrosis bronchial epithelial repair processes after injury

Am J Physiol Lung Cell Mol Physiol. 301(6):L945-55. 

 

L. Chami-Giovannini, N. Grandvaux, B. Marcet, L.E Zaragosi, K. Robbe-Sermesant, B. Cardinaud, C. Coraux, Y. Berthiaume, R. Waldmann, B. Mari and P. Barbry (2011). Impact of microRNA in normal and pathological respiratory epithelia. In M.D. Amaral, K. and Kunzelmann (Ed), Methods in Molecular Biology Vol. 741, Cystic Fibrosis Protocols and Diagnosis, 1st edition Springer, Humana Press, pages 171-91.

 

F. Dufour, L. Bertrand, A. Pearson, N. Grandvaux and Y Langelier (2011).

The ribonucleotide reductase R1 subunits of herpes simplex type 1 and 2 protect cells against poly(I:C)-induced apoptosis

J. Virol. 85:8689-701.

P. Monteiro, A. Gosselin, V. S. Wacleche, M. El-Far, N. Grandvaux, M. R. Boulassel, J.P. Routy and P. Ancuta (2011)

Memory CCR6+CD4+ T-Cells are Preferential Targets for Productive HIV-1 Infection Regardless of their Expression of Integrin Beta7

J. Immunol. 186(8):4618-30. 

N. Grandvaux (2011)

The IKKε kinase in breast cancer : from oncogenesis to treatment resistance.

Med. Sci. 27(6-7):619-625.  

2010

F. Yoboua$, A. Martel$, A. Duval, E. Mukawera and N. Grandvaux * (2010).

Respiratory-Syncytial Virus-mediated NF-kappaB p65 phosphorylation at Serine 536 is dependent on RIG-I, TRAF6 and IKKbeta.

J. Virol. 84(11):7267-77. 

A. Soucy-Faulkner, E. Mukawera, K. Fink, A. Martel, L. Jouan, Y. Nzengue, D. Lamarre, C. Vande Velde and N. Grandvaux* (2010).

Requirement of NOX2 and Reactive Oxygen Species for efficient RIG-I-mediated antiviral response through regulation of MAVS expression.

PloS Pathogens 6(6):e1000930. 

Jouan L., Melançon P., Rodrigue-Gervais I.G., Raymond V., Selliah S., Bilodeau M., Grandvaux N. and Lamarre D (2010).

Distinct Antiviral Signaling Pathways in Primary Human Hepatocytes and their Differential Disruption by HCV NS3 Protease.

J. Hepatol. 52(2):167-75. 

2008

K. Fink, A. Duval, A. Martel, A.Soucy-Faulkner, and N. Grandvaux * (2008).

Dual role of NOX2 in the regulation of NF-B activation during Respiratory Syncytial Virus and Sendai Virus infection of Airway Epithelial Cells.

J. Immunol. 180:6911-6922. 

J.F. Clement, A. Bibeau-Poirier, S. P. Gravel, N. Grandvaux, E. Bonneil, P. Thibault, S. Meloche and M. Servant (2008).

Phosphorylation of IRF-3 on Ser339 generates a hyperactive form of IRF-3 through regulation of dimerization and CBP association.

J. Virol. 82:3984-96. IF: 5.15

2007

A. Lezin, N. Gillet, S. Olindo, A. Signate, N. Grandvaux, O. Verlaeten, M. Carvalho de Bittencourt, J. Hiscott, B. Asquith, A. Burny, D. Smadja, R. Césaire and L. Willems (2007)

Histone deacetylase mediated transcriptional activation reduces proviral loads in HTLV-1-associated myelopathy/tropical spastic paraparesis patients       

Blood. 110:3722-8. 

N. Cloutier, N. Grandvaux and L. Flamand (2007)

Synergestic activation of the interferon beta gene by the viral flice inhibitory protein of karposi’s sarcoma-associated herpesvirus and type 1 interferon activators

Eur. J. Immunol. 37:2772-2778. 

S. Lefort, A. Soucy-Faulkner, N. Grandvaux and L. Flamand (2007)

Kaposi’s sarcoma-associated herpesvirus K-bZIP protein activates to better suppress interferon beta gene expression.

J. Virol. 81:10950-60. 

N. Grandvaux, A. Soucy-Faulkner and K. Fink (2007)

Innate host defense : Nox and Duox on phox’s tail!

Biochimie. 89:1113-22 

J. Jaworska, A. Gravel, K. Fink, N. Grandvaux and L. Flamand (2007)

Human Herpesvirus 6 immediate-early 1 protein blocks IRF3-dependent gene activation including beta-interferon.

J. Virol. 81:5737-48 

R. Romieu-Mourez, M. Solis, D. Goubau, N. Grandvaux, A. Nardini, M. Salcedo and J. Hiscott  (2007)

Involvement of TBK-1 and IKK in LPS-induced activation of the interferon response in primary human macrophages and macrophages activated killer cells.

Eur. J. Immunol. 37(2):528-39. 

2006

A. Bibeau-Poirier, S.P. Gravel, J.F. Clément, S. Rolland, G. Rodier, P. Coulombe, J. Hiscott, N. Grandvaux, S. Meloche and M. J. Servant (2006).

Involvement of the IKK-related kinases TBK1/IKKi and Cullin-based Ubiquitin Ligases in Virus-Mediated IRF-3 Degradation.

J. Immunol. 177:5059-67 

Harris J., Sharma S., Sun Q., Olière S., Lin R., Hiscott J. and Grandvaux N*. (2006)

Carboxyl terminal phosphorylation by IKKe controls nuclear accumulation of cRel.

J. Immunol. 177(4):2527-35

Bannwarth S., Laine S., Daher A., Grandvaux N., Leblanc A., Hiscott J. and Gatignol A (2006).

NF-Y/CBF transcription factor mediates a specific upregulation of the tarbp2 promoter gene expression in a lymphocytic and an astrocytic cell line.

J. Mol. Biol. 3(5):898-910 IF: 4.89

2005

Grandvaux N., Harris J., tenOever B.R., Lin R. and Hiscott J. (2005)

Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response.

FEBS journal. 272. 3120-31. 

 

Desfosses Y., Solis M., Sun Q., Grandvaux N., VanLint C., Burny A., Lin R. and Hiscott J. (2005).

Regulation of HIV-1 Gene expression by Clade specific Tat proteins.

J. Virol. 79. 9180-91. 

Breiman A., Grandvaux N., Lin R., Ottone C., Akira S., Yoneyama M., Fujita T., Hiscott J. and Meurs E. (2005).

Inhibition of RIG-I dependent signaling to the interferon pathway during hepatitis C expression and restoration of signaling by IKKe

J. Virol. 79, 3969-3978